持續近兩(liang)個多(duo)月(yue)的新型冠狀病毒(du)感染的肺炎疫情牽動著每一個人的心(xin)，為(wei)了打贏這(zhe)場疫情防控狙擊戰(zhan)，搞(gao)清(qing)致病機理(li)，研發抗病毒藥物和疫苗刻(ke)不容緩。Jena bioscience品(pin)牌有豐富的抗病毒核苷酸(suan)/核苷酸類似物，助力抗(kang)病毒藥物研(yan)發。
抗病毒核苷及核苷酸類似物主要有:
抗病毒(du)核苷/核苷酸類似物可(ke)以通過(guo)抑(yi)制病(bing)毒(du)復制的幾(ji)個關(guan)鍵過(guo)程來抑(yi)制病(bing)毒(du)繁殖，它們通過與天然的dNTP/NTP競爭結合到新(xin)的(de)病毒核(he)酸(suan)中，從而導致鏈終止或者誘變。在細胞培養實(shi)驗(yan)中，可以用(yong)抗病毒(du)核苷(gan)酸(suan)的(de)非磷酸(suan)化核苷(gan)變體，這種核苷(gan)酸(suan)在(zai)細胞內被多種病毒(du)和(he)/或宿主(zhu)激酶激活，從而發揮(tri)磷(lin)酸化形式的抗(kang)病毒作用。
熱銷抗病毒核苷/核苷酸(suan)類(lei)似物(wu)：
|
品牌 |
貨號 |
品名 |
規格 |
|
Jena Bioscience |
NU-1605S |
3TCMP |
10 μl (10 mM) |
|
Jena Bioscience |
NU-1605L |
3TCMP |
5 x 10 μl (10 mM) |
|
Jena Bioscience |
NU-1606S |
3TCTP |
5 μl (10 mM) |
|
Jena Bioscience |
NU-1606L |
3TCTP |
5 x 5 μl (10 mM) |
|
Jena Bioscience |
NU-1603S |
d4TMP |
20 μl (10 mM) |
|
Jena Bioscience |
NU-1603L |
d4TMP |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
NU-1601S |
AzTMP |
20 μl (10 mM) |
|
Jena Bioscience |
NU-1601L |
AzTMP |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
NU-989S |
AzTTP |
10 μl (100 mM) |
|
Jena Bioscience |
NU-989L |
AzTTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-875 ; |
ara-Adenosine-5'-monophosphate (ara-AMP) |
2 mg |
|
Jena Bioscience |
NU-1111S |
50 μl (10 mM) |
|
|
Jena Bioscience |
NU-1111L |
ara-Adenosine-5'-triphosphate (ara-ATP) |
5 x 50 μl (10 mM) |
|
Jena Bioscience |
NU-876 |
Acyclovir-5'-monophosphate |
2 mg |
|
Jena Bioscience |
NU-877 |
Acyclovir-5'-triphosphate |
2 mg |
|
Jena Bioscience |
NU-021-2 |
Ribavirin-5'-monophosphate |
2 mg |
|
Jena Bioscience |
NU-1105S |
20 μl (10 mM) |
|
|
Jena Bioscience |
NU-1105L |
Ribavirin-triphosphate |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
N-DN-8234-100 |
β-L-2'-Deoxythymidine |
100 mg |
|
Jena Bioscience |
NU-896S |
10 μl (100 mM) |
|
|
Jena Bioscience |
NU-896L |
6-Aza-UTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-974 |
Tenofovir |
100 mg |
|
Jena Bioscience |
NU-975 |
Tenofovir-diphosphate |
1 mg |
|
Jena Bioscience |
NU-989S |
10 μl (100 mM) |
|
|
Jena Bioscience |
NU-989L |
AzTTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-275S |
10 μl |
|
|
Jena Bioscience |
NU-275L |
Ganciclovir-triphosphate |
5 x 10 μl |
西美杰是(shi)Jena bioscience中(zhong)國總代理，為用戶提供完(wan)善(shan)的技術與(yu)售(shou)后服務。如對產品感興趣歡(huan)迎撥打西(xi)美(mei)杰客服熱線400-050-4006了解詳細信息。西美杰會更好的協助科研(yan)工作者的實驗工作，支(zhi)持全國戰(zhan)“疫”，早日戰勝病毒。武漢(han)加油(you)！中(zhong)國加油(you)！
參考文(wen)獻：
1] Huang at al. (2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12:18.
[2] Vaccaro at al. (1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP. Antimicrob. Agents Chemother. 44 (1):217.
[3] Jaju at al. (1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. J. Biol. Chem. 270 (17):9740.
[4] Furmann at al. (1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate. J. Virol. 29 (2):154.
[5] Muller at al. (1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems. Ann. N.Y. Acad. Sci. 284:34.
[6] Crotty at al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 6 (12):1375.
[7] Ray at al. (2009) Metabolism of antiviral nucleosides and nucleotides. In: Antiviral Research: Strategies in antiviral drug discovery (LaFemina). ASM Press.
[8] Simons at al. (2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics. Current Topics in Medicinal Chemistry 5:1191.
